SCHEMBL20005236

SCHEMBL20005236

CCCCc1ccc(-c2ccc(CCc3cc(F)c(-c4c(F)cc(C#Cc5cc(F)ccc5CC)cc4F)c(F)c3)cc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RARB P10826 8/20 0.37
RARA P10276 1/20 0.37
RARG P13631 1/20 0.37
FFAR1 O14842 3/20 0.35
FFAR4 Q5NUL3 2/20 0.35
TSHR P16473 1/20 0.34
HSD17B10 Q99714 1/20 0.34
EIF4A1 P60842 2/20 0.34
GPR84 Q9NQS5 1/20 0.33
DHODH Q02127 1/20 0.33
AKR1C2 P52895 1/20 0.32
AKR1C1 Q04828 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19999538 0.85 RARB (0.41) RARBRARARARGTSHRHSD17B10
SCHEMBL20005237 0.77 FFAR1 (0.35) FFAR1FFAR4
SCHEMBL22984238 0.77 FFAR1 (0.43) RARBRARARARGFFAR1FFAR4
SCHEMBL19412419 0.76 GPR84 (0.33) RARBRARARARGFFAR1FFAR4
SCHEMBL20006810 0.76 FFAR1 (0.39) FFAR1FFAR4TSHRHSD17B10
SCHEMBL20006847 0.76 HRH3 (0.36) FFAR1FFAR4
SCHEMBL19999391 0.72 RARB (0.36) RARBRARARARGFFAR1FFAR4
SCHEMBL7851724 0.72 FFAR1 (0.47) RARBRARARARGFFAR1FFAR4
SCHEMBL7851722 0.72 FFAR1 (0.43) FFAR1FFAR4
SCHEMBL7857712 0.72 FFAR1 (0.43) FFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10208249-B2 Liquid crystal compound, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2019-02-19 US disclosed
US-20180086979-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2018-03-29 US disclosed
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed