Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27174137 | 0.93 | KMT2A (0.58) | KMT2AMEN1NPC1HSP90AA1L3MBTL1 | |
| SCHEMBL29625837 | 0.93 | KMT2A (0.58) | KMT2AMEN1NPC1HSP90AA1L3MBTL1 | |
| SCHEMBL148991 | 0.93 | KMT2A (0.58) | KMT2AMEN1NPC1HSP90AA1L3MBTL1 | |
| Triphenylene SCHEMBL29177920 | 0.91 | KMT2A (0.56) | KMT2AMEN1NPC1HSP90AA1L3MBTL1 | |
| Acetic Acid SCHEMBL7978947 | 0.87 | KMT2A (0.45) | KMT2AMEN1NPC1HSP90AA1L3MBTL1 | |
| Pyridine SCHEMBL15673026 | 0.85 | KMT2A (0.50) | KMT2AMEN1NPC1HSP90AA1L3MBTL1 | |
| Dibenzothiophene SCHEMBL28528093 | 0.82 | KMT2A (0.47) | KMT2AMEN1NPC1HSP90AA1L3MBTL1 | |
| SCHEMBL16482063 | 0.81 | NPC1 (0.44) | KMT2AMEN1NPC1HSP90AA1L3MBTL1 | |
| SCHEMBL15835964 | 0.81 | NPC1 (0.44) | KMT2AMEN1NPC1HSP90AA1L3MBTL1 | |
| SCHEMBL15835963 | 0.81 | NPC1 (0.44) | KMT2AMEN1NPC1HSP90AA1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220218676-A1 | CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2022-07-14 | — | — | US | disclosed |
| US-20210015800-A1 | CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. | 2021-01-21 | — | — | US | disclosed |
| US-10806724-B2 | Chromane, isochromane and dihydroisobenzofuran derivatives as mGluR2-negative allosteric modulators, compositions, and their use | MERCK SHARP & DOHME CORP. (US) | 2020-10-20 | — | — | US | disclosed |
| US-20190247374-A1 | CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2019-08-15 | — | — | US | disclosed |
| US-10335399-B2 | Chromane, isochromane and dihydroisobenzofuran derivatives as mGluR2—negative allosteric modulators, compositions, and their use | MERCK SHARP & DOHME CORP. | 2019-07-02 | — | — | US | disclosed |
| US-20180085358-A1 | CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210015800-A1 | CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE | GRM2, GRIN2A, GRIA2 | KMT2A 329/4885MEN1 3344/4885NPC1 409/4885 |
| US-20220218676-A1 | CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE | GRM2, GRIN2A, GRIA2 | KMT2A 353/4885MEN1 3984/4885NPC1 374/4885 |
| US-10335399-B2 | Chromane, isochromane and dihydroisobenzofuran derivatives as mGluR2—negative allosteric modulators, compositions, and their use | GRM2, GRIN2A, GRIA2 | KMT2A 344/4885MEN1 3719/4885NPC1 400/4885 |
| US-20190247374-A1 | CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE | GRM2, GRIN2A, GRIA2 | KMT2A 353/4885MEN1 3984/4885NPC1 374/4885 |
| US-10806724-B2 | Chromane, isochromane and dihydroisobenzofuran derivatives as mGluR2-negative allosteric modulators, compositions, and their use | GRM2, GRIN2A, GRIA2 | KMT2A 351/4885MEN1 3762/4885NPC1 397/4885 |
| US-20180085358-A1 | CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE | GRM2, GRIN2A, GRIA2 | KMT2A 351/4885MEN1 3762/4885NPC1 397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.