Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP26 | Q9BV47 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | IKBKB | O14920 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MITF | O75030 | 2/20 | 0.58 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.57 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | NSD2 | O96028 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18103077 | 1.00 | DUSP26 (0.65) | DUSP26MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL18102922 | 0.85 | DUSP26 (0.58) | DUSP26MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL18102934 | 0.81 | DUSP26 (0.75) | DUSP26MAPTIKBKBMEN1KMT2A | |
| SCHEMBL5281534 | 0.78 | MAPK1 (0.72) | MAPTALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL5281527 | 0.78 | MAPK1 (0.72) | MAPTALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL5281537 | 0.78 | MAPK1 (0.72) | MAPTALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL18103079 | 0.77 | MAPK1 (0.78) | MAPTALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL20006042 | 0.77 | MAPK1 (0.78) | MAPTALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL20006090 | 0.76 | DUSP22 (0.80) | DUSP26MEN1KMT2ARAB9ABCL2 | |
| SCHEMBL18103078 | 0.76 | DUSP22 (0.80) | DUSP26MEN1KMT2ARAB9ABCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | UNIVERSITY OF MIAMI (US) | 2019-12-10 | — | — | US | disclosed |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | NOTCH1, CBFB, HES1 | DUSP26 2207/4885MAPT 3938/4885ALDH1A1 2177/4885 |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NOTCH1, CBFB, HES1 | DUSP26 2207/4885MAPT 3938/4885ALDH1A1 2177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.