Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | BLM | P54132 | 1/20 | 0.66 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 3/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.63 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.62 |
| ▸ | CLK1 | P49759 | 1/20 | 0.62 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.62 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.62 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.61 |
| ▸ | MMP3 | P08254 | 2/20 | 0.60 |
| ▸ | MMP13 | P45452 | 2/20 | 0.60 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.57 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19999097 | 1.00 | MEN1 (0.66) | MEN1POLBKMT2ABLMNOD2 | |
| SCHEMBL8310047 | 0.87 | PIM1 (0.68) | MEN1POLBKMT2ABLMNOD2 | |
| SCHEMBL1249348 | 0.87 | PIM1 (0.71) | MEN1POLBKMT2ABLMNOD2 | |
| SCHEMBL1249347 | 0.87 | PIM1 (0.71) | MEN1POLBKMT2ABLMNOD2 | |
| SCHEMBL18102861 | 0.86 | GSK3B (0.85) | MEN1POLBKMT2ABLMNOD2 | |
| SCHEMBL13846898 | 0.86 | PIM1 (0.67) | MEN1POLBKMT2ABLMNOD2 | |
| SCHEMBL19999089 | 0.85 | GSK3B (0.84) | MEN1POLBKMT2ABLMNOD2 | |
| SCHEMBL8714351 | 0.84 | PIM1 (0.80) | MEN1POLBKMT2ABLMNOD2 | |
| SCHEMBL8714355 | 0.84 | PIM1 (0.80) | MEN1POLBKMT2ABLMNOD2 | |
| SCHEMBL31482534 | 0.82 | MEN1 (0.67) | MEN1POLBKMT2ABLMNOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | UNIVERSITY OF MIAMI (US) | 2019-12-10 | — | — | US | disclosed |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | NOTCH1, CBFB, HES1 | MEN1 846/4885POLB 1009/4885KMT2A 470/4885 |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NOTCH1, CBFB, HES1 | MEN1 846/4885POLB 1009/4885KMT2A 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.