Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.31 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21512512 | 0.76 | HTT (0.41) | MALT1RXFP1AAK1HTTTSHR | |
| SCHEMBL29969729 | 0.76 | HTT (0.41) | MALT1RXFP1AAK1HTTTSHR | |
| SCHEMBL29968478 | 0.73 | HTT (0.39) | MALT1RXFP1AAK1HTTTSHR | |
| SCHEMBL21512507 | 0.73 | HTT (0.39) | MALT1RXFP1AAK1HTTTSHR | |
| SCHEMBL20006099 | 0.72 | IRAK4 (0.37) | RXFP1AAK1HTTABL1IRAK4 | |
| SCHEMBL28537583 | 0.71 | MAPK1 (0.35) | RXFP1HTTTSHRALDH1A1USP2 | |
| SCHEMBL18843813 | 0.68 | RXFP1 (0.38) | MALT1RXFP1HTTTSHRALDH1A1 | |
| SCHEMBL21561046 | 0.66 | MALT1 (0.39) | MALT1RXFP1AAK1HTTTSHR | |
| SCHEMBL21512626 | 0.66 | MAPK1 (0.37) | RXFP1HTTTSHRALDH1A1KMT2A | |
| SCHEMBL19003377 | 0.64 | AAK1 (0.41) | AAK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140303-B1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2018-03-28 | — | — | EP | disclosed |