Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20006105 | 0.72 | MALT1 (0.35) | IRAK4HTTMEN1POLBKMT2A | |
| SCHEMBL1543907 | 0.68 | SLC22A12 (0.49) | IRAK4SLC22A12NCF1HTTMEN1 | |
| SCHEMBL2621813 | 0.68 | IRAK4 (0.46) | IRAK4SLC22A12NCF1GAKEPHB6 | |
| SCHEMBL9034955 | 0.66 | SLC22A12 (0.50) | SLC22A12NCF1HTTMAPK1FLT3 | |
| SCHEMBL28823329 | 0.66 | SLC22A12 (0.53) | SLC22A12NCF1HTTMAPTFLT3 | |
| SCHEMBL5499754 | 0.66 | HTT (0.60) | SLC22A12NCF1HTTFLT3CHEK1 | |
| SCHEMBL18843813 | 0.65 | RXFP1 (0.38) | IRAK4HTTMEN1POLBKMT2A | |
| SCHEMBL1543989 | 0.64 | NCF1 (0.70) | IRAK4NCF1HTTMAPTMAPK1 | |
| SCHEMBL20392661 | 0.64 | NCF1 (0.47) | IRAK4SLC22A12NCF1FLT3CHEK1 | |
| SCHEMBL2621810 | 0.63 | IRAK4 (0.54) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140303-B1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2018-03-28 | — | — | EP | disclosed |