Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 15/20 | 0.60 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.50 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.45 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.45 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1886664 | 0.88 | CRACR2A (0.77) | CRACR2AORAI1 | |
| SCHEMBL1887682 | 0.81 | CRACR2A (0.71) | CRACR2AORAI1 | |
| SCHEMBL20041782 | 0.76 | ORAI1 (0.59) | CRACR2AORAI1 | |
| SCHEMBL12637985 | 0.76 | CRACR2A (0.60) | CRACR2A | |
| SCHEMBL1671515 | 0.75 | CRACR2A (1.00) | CRACR2AORAI1 | |
| SCHEMBL1667966 | 0.74 | CRACR2A (0.81) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL1668387 | 0.74 | CRACR2A (0.78) | CRACR2AORAI1 | |
| SCHEMBL20006441 | 0.73 | CRACR2A (0.58) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL1668375 | 0.73 | CRACR2A (1.00) | CRACR2AORAI1 | |
| SCHEMBL1667877 | 0.73 | CRACR2A (1.00) | CRACR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299361-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | Rhizen Pharmaceuticals S.A. (CH) | 2018-03-28 | — | — | EP | disclosed |