Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.73 |
| ▸ | IGF1R | P08069 | 3/20 | 0.73 |
| ▸ | EGFR | P00533 | 2/20 | 0.73 |
| ▸ | CDC7 | O00311 | 1/20 | 0.73 |
| ▸ | PLK4 | O00444 | 1/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.73 |
| ▸ | AURKA | O14965 | 1/20 | 0.73 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.73 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.73 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.73 |
| ▸ | JAK2 | O60674 | 1/20 | 0.73 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.73 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.73 |
| ▸ | PAK4 | O96013 | 1/20 | 0.73 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.73 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.73 |
| ▸ | PRKCG | P05129 | 1/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007143 | 0.85 | ALK (0.75) | ALKIGF1REGFRCDC7PLK4 | |
| SCHEMBL20006830 | 0.84 | ALK (1.00) | ALKIGF1REGFRCDC7PLK4 | |
| SCHEMBL16769548 | 0.81 | ALK (1.00) | ALKEGFR | |
| SCHEMBL12729209 | 0.74 | ALK (0.79) | ALKIGF1REGFRCDC7PLK4 | |
| SCHEMBL4095269 | 0.73 | ALK (0.81) | ALKIGF1REGFRCDC7PLK4 | |
| SCHEMBL4096523 | 0.73 | ALK (0.80) | ALKIGF1REGFRCDC7PLK4 | |
| SCHEMBL380944 | 0.72 | ULK1 (0.88) | ALKIGF1REGFRCDC7PLK4 | |
| SCHEMBL30682433 | 0.72 | ALK (0.84) | ALKIGF1RINSRMAPK3 | |
| SCHEMBL16769540 | 0.72 | ALK (1.00) | ALK | |
| SCHEMBL16769541 | 0.72 | ALK (0.82) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018058098-A1 | COMPOUNDS AND METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE | YALE UNIVERSITY (US) | 2018-03-29 | — | — | WO | disclosed |