Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.72 |
| ▸ | CDK1 | P06493 | 7/20 | 0.72 |
| ▸ | CDK2 | P24941 | 5/20 | 0.72 |
| ▸ | IGF1R | P08069 | 5/20 | 0.72 |
| ▸ | GSK3B | P49841 | 3/20 | 0.72 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.72 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.72 |
| ▸ | KDR | P35968 | 3/20 | 0.72 |
| ▸ | CDC7 | O00311 | 2/20 | 0.72 |
| ▸ | PLK4 | O00444 | 2/20 | 0.72 |
| ▸ | AURKA | O14965 | 2/20 | 0.72 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.72 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.72 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.72 |
| ▸ | JAK2 | O60674 | 2/20 | 0.72 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.72 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.72 |
| ▸ | PAK4 | O96013 | 2/20 | 0.72 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.72 |
| ▸ | ABL1 | P00519 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20006842 | 0.84 | SYK (1.00) | SYKCDK1CDK2IGF1RGSK3B | |
| SCHEMBL19312723 | 0.78 | SYK (0.83) | SYKCDK1CDK2IGF1RGSK3B | |
| SCHEMBL1197543 | 0.74 | SYK (0.80) | SYKCDK1CDK2IGF1RGSK3B | |
| SCHEMBL4007188 | 0.74 | SYK (0.81) | SYKCDK1CDK2IGF1RGSK3B | |
| SCHEMBL4001373 | 0.74 | JAK3 (0.81) | SYKCDK1CDK2IGF1RGSK3B | |
| SCHEMBL1197903 | 0.72 | SYK (0.75) | SYKCDK1CDK2IGF1RGSK3B | |
| SCHEMBL1197404 | 0.71 | SYK (0.75) | SYKCDK1CDK2IGF1RGSK3B | |
| SCHEMBL2842574 | 0.71 | IGF1R (0.54) | SYKCDK1CDK2IGF1RGSK3B | |
| SCHEMBL4002770 | 0.70 | JAK3 (0.62) | SYKCDK1CDK2IGF1RGSK3B | |
| SCHEMBL4001007 | 0.70 | SYK (0.67) | SYKCDK1CDK2IGF1RGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018058098-A1 | COMPOUNDS AND METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE | YALE UNIVERSITY (US) | 2018-03-29 | — | — | WO | disclosed |