Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 1.00 |
| ▸ | CDK1 | P06493 | 5/20 | 1.00 |
| ▸ | CDK2 | P24941 | 5/20 | 1.00 |
| ▸ | JAK3 | P52333 | 5/20 | 1.00 |
| ▸ | KDR | P35968 | 4/20 | 1.00 |
| ▸ | PTK2 | Q05397 | 3/20 | 1.00 |
| ▸ | IGF1R | P08069 | 3/20 | 1.00 |
| ▸ | JAK2 | O60674 | 3/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 3/20 | 1.00 |
| ▸ | CDC7 | O00311 | 2/20 | 1.00 |
| ▸ | PLK4 | O00444 | 2/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 2/20 | 1.00 |
| ▸ | AURKA | O14965 | 2/20 | 1.00 |
| ▸ | DCLK1 | O15075 | 2/20 | 1.00 |
| ▸ | PDPK1 | O15530 | 2/20 | 1.00 |
| ▸ | DAPK3 | O43293 | 2/20 | 1.00 |
| ▸ | ROCK2 | O75116 | 2/20 | 1.00 |
| ▸ | MAP4K4 | O95819 | 2/20 | 1.00 |
| ▸ | PAK4 | O96013 | 2/20 | 1.00 |
| ▸ | CHEK2 | O96017 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4007188 | 0.90 | SYK (0.81) | SYKCDK1CDK2JAK3KDR | |
| SCHEMBL4001373 | 0.90 | JAK3 (0.81) | SYKCDK1CDK2JAK3KDR | |
| SCHEMBL20006841 | 0.84 | SYK (0.72) | SYKCDK1CDK2JAK3KDR | |
| SCHEMBL4002229 | 0.83 | SYK (0.71) | SYKCDK1CDK2JAK3KDR | |
| SCHEMBL1474170 | 0.83 | JAK3 (0.70) | SYKCDK1CDK2JAK3KDR | |
| SCHEMBL5025579 | 0.81 | SYK (0.68) | SYKCDK1CDK2JAK3KDR | |
| SCHEMBL1474794 | 0.80 | SYK (0.67) | SYKCDK1CDK2JAK3KDR | |
| SCHEMBL1475188 | 0.80 | JAK3 (0.67) | SYKCDK1CDK2JAK3KDR | |
| SCHEMBL1474824 | 0.80 | JAK3 (0.74) | SYKCDK1CDK2JAK3KDR | |
| SCHEMBL4001007 | 0.80 | SYK (0.67) | SYKCDK1CDK2JAK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190275040-A1 | COMPOUNDS AND METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE | UNIV YALE (US) | 2019-09-12 | — | — | US | disclosed |
| WO-2018058098-A1 | COMPOUNDS AND METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE | YALE UNIVERSITY (US) | 2018-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190275040-A1 | COMPOUNDS AND METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE | FYN, DAPK2, DAPK1 | SYK 187/4885CDK1 1346/4885CDK2 787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.