Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27823838 | 0.90 | PTPN1 (0.62) | HMGCRPTPN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL27903897 | 0.90 | HMGCR (0.56) | HMGCRPTPN1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL27803198 | 0.86 | HMGCR (0.51) | HMGCRPTPN1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL514174 | 0.83 | MAPT (0.47) | HMGCRPTPN1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL4302772 | 0.81 | LCK (0.59) | PTPN1SMN1; SMN2MAPTRAB9AALDH1A1 | |
| SCHEMBL27803206 | 0.80 | HMGCR (0.51) | HMGCRPTPN1ALDH1A1KDM4ETSHR | |
| SCHEMBL21635979 | 0.79 | KDM4E (0.65) | PTPN1SMN1; SMN2MAPTRAB9AALDH1A1 | |
| SCHEMBL28257934 | 0.79 | PTPN1 (0.57) | PTPN1SMN1; SMN2MAPTRAB9AALDH1A1 | |
| SCHEMBL16168327 | 0.79 | HMGCR (0.54) | HMGCRPTPN1ALDH1A1KDM4EPOLB | |
| SCHEMBL16163314 | 0.79 | SMN1; SMN2 (0.56) | PTPN1SMN1; SMN2MAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2942345-B1 | 3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES FOR THE TREATMENT OF CANCER | COUNCIL SCIENT IND RES (IN) | 2018-03-28 | — | — | EP | disclosed |
| CN-102939286-A | Polysubstituted benzofurans and medicinal applications thereof | IKERCHEM S L | 2013-02-20 | — | — | CN | disclosed |