Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 20/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21144295 | 0.94 | TRPV4 (0.78) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007704 | 0.94 | TRPV4 (0.78) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL21144343 | 0.88 | TRPV4 (0.60) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL21144342 | 0.88 | TRPV4 (0.60) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007685 | 0.84 | TRPV4 (0.73) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL21172099 | 0.83 | TRPV4 (0.84) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL29355678 | 0.83 | TRPV4 (0.84) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007232 | 0.83 | TRPV4 (0.84) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007814 | 0.82 | TRPV4 (0.73) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL19995392 | 0.82 | TRPV4 (0.73) | TRPV4CYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |