Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30266466 | 1.00 | TRPV4 (1.00) | TRPV4KCNH2CYP3A4TRPM8 | |
| SCHEMBL20007624 | 1.00 | TRPV4 (1.00) | TRPV4KCNH2CYP3A4TRPM8 | |
| SCHEMBL30266235 | 1.00 | TRPV4 (1.00) | TRPV4KCNH2CYP3A4TRPM8 | |
| SCHEMBL20007723 | 1.00 | TRPV4 (1.00) | TRPV4KCNH2CYP3A4TRPM8 | |
| Hydrochloric Acid SCHEMBL29355695 | 0.99 | TRPV4 (0.98) | TRPV4KCNH2CYP3A4TRPM8 | |
| Hydrochloric Acid SCHEMBL29351064 | 0.99 | TRPV4 (0.98) | TRPV4KCNH2CYP3A4TRPM8 | |
| SCHEMBL29354470 | 0.96 | TRPV4 (0.93) | TRPV4KCNH2CYP3A4TRPM8 | |
| Water SCHEMBL30266240 | 0.96 | TRPV4 (0.93) | TRPV4KCNH2CYP3A4TRPM8 | |
| SCHEMBL21144476 | 0.94 | TRPV4 (1.00) | TRPV4KCNH2CYP3A4 | |
| SCHEMBL20007698 | 0.94 | TRPV4 (1.00) | TRPV4KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515887-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2021-07-07 | — | — | EP | disclosed |
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |