Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 19/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23614022 | 0.90 | TRPV4 (0.43) | TRPV4CYP3A4KCNH2S1PR3 | |
| SCHEMBL20007806 | 0.80 | TRPV4 (0.59) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007587 | 0.78 | TRPV4 (0.57) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL23614002 | 0.76 | TRPV4 (0.48) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007246 | 0.75 | TRPV4 (0.65) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007458 | 0.75 | TRPV4 (0.51) | TRPV4CYP3A4KCNH2S1PR3 | |
| SCHEMBL23614050 | 0.73 | TRPV4 (0.51) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007569 | 0.72 | TRPV4 (0.52) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007330 | 0.72 | TRPV4 (0.52) | TRPV4CYP3A4KCNH2S1PR3 | |
| SCHEMBL20007702 | 0.72 | TRPV4 (0.54) | TRPV4CYP3A4KCNH2S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |