Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 20/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21144291 | 1.00 | TRPV4 (0.80) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL21144399 | 0.94 | TRPV4 (0.79) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007705 | 0.94 | TRPV4 (0.79) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007683 | 0.92 | TRPV4 (0.70) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL21144247 | 0.90 | TRPV4 (0.85) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007585 | 0.90 | TRPV4 (0.85) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL19995625 | 0.90 | TRPV4 (0.84) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL30266300 | 0.90 | TRPV4 (0.84) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007450 | 0.90 | TRPV4 (0.84) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL21144357 | 0.89 | TRPV4 (0.80) | TRPV4CYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |