Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CPT1A | P50416 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 5/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565364 | 0.90 | CYP2C9 (0.55) | CYP2C9CPT1ARORCPSEN1PSEN2 | |
| SCHEMBL12569920 | 0.90 | RORC (0.57) | CYP2C9CPT1ARORCNR1H3NR1H2 | |
| SCHEMBL2001117 | 0.88 | CPT1A (0.56) | CYP2C9CPT1ARORCNR1H3MAPT | |
| SCHEMBL2002839 | 0.88 | RORC (0.48) | CYP2C9CPT1ARORCNR1H3NR1H2 | |
| SCHEMBL2000444 | 0.87 | RORC (0.49) | CYP2C9CPT1ARORCNR1H3NR1H2 | |
| SCHEMBL2004004 | 0.87 | RORC (0.47) | CYP2C9CPT1ARORCNR1H3NR1H2 | |
| SCHEMBL2003116 | 0.87 | CPT1A (0.48) | CYP2C9CPT1ARORCNR1H3NR1H2 | |
| SCHEMBL2001074 | 0.86 | CPT1A (0.47) | CYP2C9CPT1ARORCNR1H3NR1H2 | |
| SCHEMBL2009528 | 0.84 | RORC (0.45) | CYP2C9CPT1ARORCNR1H3NR1H2 | |
| SCHEMBL2002539 | 0.84 | RORC (0.44) | CYP2C9CPT1ARORCNR1H3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960377-B2 | Substituted pyridoxazines | CARA THERAPEUTICS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090247502-A1 | SUBSTITUTED PYRIDOXAZINES | CARA THERAPEUTICS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247502-A1 | SUBSTITUTED PYRIDOXAZINES | CNR1, CNR2, TRPV1 | CYP2C9 346/4885CPT1A 3067/4885RORC 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.