Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 8/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | VEGFA | P15692 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009436 | 0.77 | MAPK14 (0.41) | ABL1LRRK2MAPK14 | |
| SCHEMBL22811167 | 0.77 | RRM2 (0.34) | MAPT | |
| SCHEMBL20009415 | 0.74 | RAF1 (0.37) | BRAFMAPK14 | |
| SCHEMBL20008778 | 0.73 | RAF1 (0.37) | BRAFMAPK14 | |
| SCHEMBL23654969 | 0.72 | BRAF (0.33) | BRAFABL1LRRK2MAPK14LCK | |
| SCHEMBL23654398 | 0.69 | BRAF (0.36) | BRAFPIK3CDPIK3CBPIK3CGABL1 | |
| SCHEMBL18822208 | 0.68 | PRMT5 (0.41) | PIK3CDPIK3CBPIK3CG | |
| SCHEMBL13495562 | 0.68 | GRM5 (0.44) | BRAFPIK3CDPIK3CBPIK3CGABL1 | |
| SCHEMBL21021589 | 0.67 | APP (0.45) | APPABL1LRRK2MAPTMAPK14 | |
| SCHEMBL31359595 | 0.67 | SREBF2 (0.47) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |