Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.41 |
| ▸ | ABL1 | P00519 | 8/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008143 | 0.77 | BRAF (0.38) | MAPK14ABL1LRRK2 | |
| SCHEMBL20008219 | 0.73 | ABL1 (0.43) | ABL1RAF1 | |
| SCHEMBL20009446 | 0.71 | RAF1 (0.41) | RAF1 | |
| SCHEMBL21240974 | 0.70 | MAP4K4 (0.42) | — | |
| SCHEMBL27641375 | 0.67 | SYK (0.35) | LRRK2 | |
| SCHEMBL20009443 | 0.67 | RAF1 (0.37) | MAPK14RAF1HSPB1LYN | |
| SCHEMBL20008778 | 0.65 | RAF1 (0.37) | MAPK14RAF1HSPB1LYN | |
| SCHEMBL20008341 | 0.65 | RAF1 (0.38) | MAPK14RAF1 | |
| SCHEMBL20008313 | 0.65 | ROCK2 (0.41) | MAPK14RAF1HSPB1LYN | |
| SCHEMBL10229782 | 0.65 | CYP1A2 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |