Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008272 | 0.79 | TP53 (0.40) | TP53MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL15306495 | 0.68 | HPGD (0.57) | TP53MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL12846473 | 0.66 | HPGD (0.58) | MEN1KMT2ANPC1RAB9ATSHR | |
| SCHEMBL20008581 | 0.63 | TP53 (0.39) | TP53MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL25732408 | 0.62 | CYP2D6 (0.40) | TP53MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL25732476 | 0.61 | CYP2D6 (0.41) | TP53MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL18856150 | 0.60 | MEN1 (0.44) | TP53MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL24016907 | 0.59 | KMT2A (0.60) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL23011778 | 0.59 | MEN1 (0.46) | TP53MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL9720686 | 0.58 | MEN1 (0.65) | TP53MEN1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |