Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008429 | 0.71 | TP53 (0.40) | TP53RAB9ANPC1MEN1KMT2A | |
| SCHEMBL15306495 | 0.65 | HPGD (0.57) | TP53RAB9ANPC1MEN1KMT2A | |
| SCHEMBL12846473 | 0.63 | HPGD (0.58) | RAB9ANPC1MEN1KMT2AHPGD | |
| SCHEMBL20009541 | 0.63 | TP53 (0.32) | TP53RAB9ANPC1MEN1KMT2A | |
| SCHEMBL20008272 | 0.63 | TP53 (0.40) | TP53RAB9ANPC1MEN1KMT2A | |
| SCHEMBL20008223 | 0.63 | TP53 (0.39) | TP53RAB9ANPC1MEN1KMT2A | |
| SCHEMBL27451509 | 0.62 | FFAR1 (0.32) | SMN1; SMN2GAA | |
| SCHEMBL16956618 | 0.59 | MEN1 (0.42) | TP53MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL5598157 | 0.58 | ALDH1A1 (0.35) | TP53MEN1KMT2AHPGD | |
| SCHEMBL13518614 | 0.58 | MEN1 (0.49) | TP53NPC1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |