Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 6/20 | 0.55 |
| ▸ | KCNK9 | Q9NPC2 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 6/20 | 0.49 |
| ▸ | BRAF | P15056 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14308003 | 0.76 | MEN1 (0.66) | MEN1KMT2ARAB9AHTTRXFP1 | |
| SCHEMBL15238366 | 0.76 | KCNK3 (0.67) | MEN1KMT2ARAB9AHTTRXFP1 | |
| SCHEMBL259371 | 0.76 | KMT2A (0.66) | MEN1KMT2ARAB9AHTTRXFP1 | |
| SCHEMBL12764063 | 0.75 | MEN1 (1.00) | MEN1KMT2ARAB9AHTTRXFP1 | |
| SCHEMBL259421 | 0.74 | KCNK3 (0.86) | MEN1KMT2ARAB9AHTTRXFP1 | |
| SCHEMBL16094593 | 0.74 | KDM4C (0.47) | HTTLMNASMN1; SMN2ALDH1A1RAF1 | |
| SCHEMBL4253897 | 0.73 | KCNK3 (0.93) | MEN1KMT2ARAB9AHTTRXFP1 | |
| SCHEMBL22601558 | 0.73 | LMNA (0.74) | MEN1KMT2ARAB9AHTTKCNK3 | |
| SCHEMBL23309569 | 0.73 | LMNA (0.74) | RAB9AHTTKCNK3LMNASMN1; SMN2 | |
| SCHEMBL15604709 | 0.73 | MEN1 (0.82) | MEN1KMT2ARAB9AHTTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |