Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 0.56 |
| ▸ | BRAF | P15056 | 16/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16094722 | 0.75 | RAF1 (0.59) | RAF1BRAFSYKBTK | |
| SCHEMBL20008422 | 0.73 | PIK3CA (0.38) | RAF1BRAFROCK2ROCK1 | |
| SCHEMBL16121331 | 0.72 | BRAF (1.00) | RAF1BRAF | |
| SCHEMBL16121540 | 0.72 | RAF1 (1.00) | RAF1BRAF | |
| SCHEMBL20008211 | 0.72 | BRAF (0.36) | RAF1BRAF | |
| SCHEMBL16121284 | 0.71 | RAF1 (1.00) | RAF1BRAF | |
| SCHEMBL16121723 | 0.71 | BRAF (1.00) | RAF1BRAF | |
| SCHEMBL16121547 | 0.70 | RAF1 (1.00) | RAF1BRAF | |
| SCHEMBL16121628 | 0.70 | RAF1 (1.00) | RAF1BRAF | |
| SCHEMBL16121279 | 0.70 | BRAF (1.00) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |