Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | BRAF | P15056 | 14/20 | 0.37 |
| ▸ | RAF1 | P04049 | 9/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008211 | 0.91 | BRAF (0.36) | PIK3CABRAFRAF1PDCD1CD274 | |
| SCHEMBL20009647 | 0.89 | BRAF (0.47) | BRAFRAF1 | |
| SCHEMBL20008197 | 0.85 | RAF1 (0.39) | PIK3CABRAFRAF1MTORPDCD1 | |
| SCHEMBL20008259 | 0.79 | RAF1 (0.38) | BRAFRAF1 | |
| SCHEMBL20008326 | 0.78 | RAF1 (0.39) | BRAFRAF1 | |
| SCHEMBL20008213 | 0.77 | RAF1 (0.38) | PIK3CABRAFRAF1MTORPDCD1 | |
| SCHEMBL20008238 | 0.74 | KMO (0.37) | BRAFRAF1 | |
| SCHEMBL20008412 | 0.73 | RAF1 (0.56) | BRAFRAF1ROCK2ROCK1 | |
| SCHEMBL20008289 | 0.73 | RAF1 (0.37) | BRAFRAF1 | |
| SCHEMBL20009521 | 0.71 | BRAF (0.45) | PIK3CABRAFRAF1PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |