Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 10/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 7/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 6/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16095043 | 0.69 | RAF1 (0.58) | RAF1 | |
| SCHEMBL16094699 | 0.69 | RAF1 (0.58) | RAF1 | |
| SCHEMBL16094697 | 0.69 | RAF1 (0.58) | RAF1 | |
| SCHEMBL20008289 | 0.68 | RAF1 (0.37) | RAF1 | |
| SCHEMBL20008598 | 0.67 | ABL1 (0.33) | ABL1 | |
| SCHEMBL20008287 | 0.66 | RAF1 (0.44) | RAF1 | |
| SCHEMBL20009417 | 0.65 | RAF1 (0.42) | RAF1PDE10A | |
| SCHEMBL19529245 | 0.64 | RAF1 (0.47) | RAF1 | |
| SCHEMBL4674143 | 0.64 | JAK3 (0.45) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL29177364 | 0.63 | PBRM1 (0.47) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |