Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 14/20 | 0.44 |
| ▸ | BRAF | P15056 | 14/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 5/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009417 | 0.97 | RAF1 (0.42) | RAF1BRAFPIK3C3PIK3CD | |
| SCHEMBL20008265 | 0.83 | RAF1 (0.43) | RAF1BRAFPIK3C3 | |
| SCHEMBL20008154 | 0.82 | RAF1 (0.45) | RAF1BRAF | |
| SCHEMBL20008289 | 0.75 | RAF1 (0.37) | RAF1BRAF | |
| SCHEMBL20008778 | 0.69 | RAF1 (0.37) | RAF1BRAF | |
| SCHEMBL20009415 | 0.68 | RAF1 (0.37) | RAF1BRAF | |
| SCHEMBL20010419 | 0.68 | ALDH1A3 (0.36) | RAF1BRAF | |
| SCHEMBL20008331 | 0.67 | RAF1 (0.43) | RAF1BRAF | |
| SCHEMBL20008259 | 0.66 | RAF1 (0.38) | RAF1BRAF | |
| SCHEMBL20008496 | 0.66 | RAF1 (0.37) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |