Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 15/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009576 | 0.72 | RAF1 (0.40) | BRAFRAF1 | |
| SCHEMBL19068928 | 0.69 | RAF1 (0.57) | BRAFRAF1 | |
| SCHEMBL21091770 | 0.68 | RAF1 (0.56) | BRAFRAF1 | |
| SCHEMBL21877180 | 0.67 | KCNQ3 (0.63) | BRAFCYP2C9RAF1MAPK14LCK | |
| SCHEMBL24275085 | 0.66 | KCNQ3 (0.65) | BRAFCYP2C9RAF1MAPK14LCK | |
| SCHEMBL4434874 | 0.66 | KCNQ3 (0.65) | BRAFRAF1MAPK14LCKCSF1R | |
| SCHEMBL16036513 | 0.66 | KCNQ3 (0.65) | BRAFCYP2C9RAF1MAPK14LCK | |
| SCHEMBL20008530 | 0.66 | RAF1 (0.38) | BRAFRAF1 | |
| SCHEMBL26075509 | 0.66 | KCNQ3 (0.63) | BRAFCYP2C9RAF1MAPK14LCK | |
| SCHEMBL23654790 | 0.65 | RAF1 (0.50) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |