Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 19/20 | 0.40 |
| ▸ | BRAF | P15056 | 19/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009265 | 0.74 | BTK (0.45) | RAF1BRAF | |
| SCHEMBL20008497 | 0.72 | BRAF (0.45) | RAF1BRAF | |
| SCHEMBL20008132 | 0.69 | RAF1 (0.44) | RAF1BRAF | |
| SCHEMBL21091770 | 0.68 | RAF1 (0.56) | RAF1BRAF | |
| SCHEMBL20008530 | 0.66 | RAF1 (0.38) | RAF1BRAF | |
| SCHEMBL19068928 | 0.63 | RAF1 (0.57) | RAF1BRAF | |
| SCHEMBL20008137 | 0.63 | PIK3C3 (0.31) | — | |
| SCHEMBL20008505 | 0.63 | RAF1 (0.47) | RAF1BRAF | |
| SCHEMBL21877180 | 0.62 | KCNQ3 (0.63) | RAF1BRAFLMNA | |
| SCHEMBL26815890 | 0.62 | RAF1 (0.65) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |