Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.47 |
| ▸ | RAF1 | P04049 | 14/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | ARAF | P10398 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21091816 | 0.73 | BRAF (0.64) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL20009429 | 0.67 | KDM4E (0.39) | BRAFRAF1 | |
| SCHEMBL22487984 | 0.66 | BRAF (0.75) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL25260758 | 0.66 | BRAF (0.72) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL19352092 | 0.65 | BRAF (0.51) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL19352093 | 0.65 | BRAF (0.51) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488453 | 0.64 | BRAF (0.75) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL31205504 | 0.64 | BRAF (0.70) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL16100633 | 0.64 | RAF1 (1.00) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL24400749 | 0.64 | BRAF (0.57) | BRAFRAF1PDGFRBARAFDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |