Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 13/20 | 0.39 |
| ▸ | BRAF | P15056 | 9/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.37 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008518 | 0.80 | RAF1 (0.51) | RAF1BRAF | |
| SCHEMBL20008534 | 0.67 | BRAF (0.47) | RAF1BRAF | |
| SCHEMBL20010381 | 0.67 | RAF1 (0.46) | RAF1BRAF | |
| SCHEMBL20008465 | 0.66 | RAF1 (0.42) | RAF1BRAF | |
| SCHEMBL26206708 | 0.65 | RAF1 (0.53) | RAF1BRAF | |
| SCHEMBL20009117 | 0.63 | RAF1 (0.40) | KDM4EALDH1A1GAAMAPTRAF1 | |
| SCHEMBL23299960 | 0.62 | RAF1 (0.61) | RAF1BRAF | |
| SCHEMBL23299901 | 0.61 | RAF1 (0.65) | RAF1BRAF | |
| SCHEMBL23875872 | 0.61 | RAF1 (0.56) | RAF1BRAF | |
| SCHEMBL24312172 | 0.60 | RAF1 (0.51) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |