Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 7/20 | 0.36 |
| ▸ | RAF1 | P04049 | 11/20 | 0.33 |
| ▸ | BRAF | P15056 | 11/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008433 | 0.75 | PRMT5 (0.30) | — | |
| SCHEMBL20009407 | 0.62 | RAF1 (0.61) | RAF1BRAF | |
| SCHEMBL20008759 | 0.61 | RAF1 (0.43) | RAF1BRAF | |
| SCHEMBL20008396 | 0.61 | PIK3C3 (0.41) | PIK3C3PIK3CD | |
| SCHEMBL20008397 | 0.60 | PIK3C3 (0.40) | PIK3C3RAF1BRAF | |
| SCHEMBL22562093 | 0.59 | RAF1 (0.39) | RAF1BRAF | |
| SCHEMBL23654801 | 0.58 | RAF1 (0.39) | RAF1BRAF | |
| SCHEMBL22562006 | 0.57 | — | — | |
| SCHEMBL22561910 | 0.55 | — | — | |
| SCHEMBL20009314 | 0.55 | RAF1 (0.39) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |