Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 9/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008251 | 0.68 | PIK3C3 (0.40) | PIK3C3GRIN2BRAF1BRAF | |
| SCHEMBL20008622 | 0.60 | PIK3C3 (0.36) | PIK3C3RAF1BRAF | |
| SCHEMBL16926881 | 0.57 | PIK3C3 (1.00) | PIK3C3 | |
| SCHEMBL23912789 | 0.57 | PIK3C3 (0.70) | PIK3C3GRIN2B | |
| SCHEMBL20008355 | 0.54 | IDO1 (0.32) | — | |
| SCHEMBL16913939 | 0.53 | PIK3C3 (1.00) | PIK3C3 | |
| SCHEMBL16913814 | 0.53 | PIK3C3 (1.00) | PIK3C3 | |
| SCHEMBL16926401 | 0.52 | PIK3C3 (1.00) | PIK3C3 | |
| SCHEMBL20008403 | 0.52 | PIK3C3 (0.30) | PIK3C3 | |
| SCHEMBL21201442 | 0.51 | PIK3C3 (0.38) | PIK3C3GRIN2BGRIN1RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |