Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9963238 | 0.90 | OPRL1 (0.69) | OPRL1OPRM1OPRD1OPRK1CYP2D6 | |
| SCHEMBL8601751 | 0.79 | GRIN2B (0.61) | OPRL1OPRM1OPRD1OPRK1CYP2D6 | |
| SCHEMBL7331082 | 0.79 | GRIN2B (0.61) | OPRL1OPRM1OPRD1OPRK1CYP2D6 | |
| SCHEMBL7331087 | 0.79 | GRIN2B (0.61) | OPRL1OPRM1OPRD1OPRK1CYP2D6 | |
| SCHEMBL18081021 | 0.79 | OPRM1 (0.54) | OPRL1OPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL13957387 | 0.78 | OPRM1 (0.43) | OPRL1OPRM1OPRD1OPRK1CYP2D6 | |
| SCHEMBL9963240 | 0.76 | GRIN2B (0.54) | OPRL1OPRM1OPRD1OPRK1CYP2D6 | |
| SCHEMBL20012542 | 0.76 | OPRL1 (0.51) | OPRL1OPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL20008955 | 0.76 | CYP2D6 (0.44) | OPRL1OPRM1OPRD1OPRK1CYP2D6 | |
| SCHEMBL20147416 | 0.75 | OPRM1 (0.50) | OPRL1OPRM1OPRD1OPRK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10308614-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-06-04 | — | — | US | disclosed |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308614-B2 | Therapeutic compounds and uses thereof | SMARCC1, SMARCC2, SMARCA4 | OPRL1 2990/4885OPRM1 2267/4885OPRD1 3963/4885 |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | SMARCC1, SMARCC2, SMARCA4 | OPRL1 2990/4885OPRM1 2267/4885OPRD1 3963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.