Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.87 |
| ▸ | MC4R | P32245 | 1/20 | 0.74 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008969 | 1.00 | CYP2D6 (0.87) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL18704984 | 1.00 | CYP2D6 (0.87) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL7264542 | 0.93 | CYP2D6 (1.00) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL16226061 | 0.93 | CYP2D6 (1.00) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL6706135 | 0.93 | CYP2D6 (1.00) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL26241232 | 0.85 | MC4R (1.00) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL16226967 | 0.85 | CYP2D6 (0.83) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL2625061 | 0.85 | MC4R (1.00) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL19293306 | 0.85 | MC4R (1.00) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL23850144 | 0.84 | CYP2D6 (0.83) | CYP2D6MC4ROPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10308614-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-06-04 | — | — | US | disclosed |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308614-B2 | Therapeutic compounds and uses thereof | SMARCC1, SMARCC2, SMARCA4 | CYP2D6 4116/4885MC4R 2221/4885OPRM1 2267/4885 |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | SMARCC1, SMARCC2, SMARCA4 | CYP2D6 4116/4885MC4R 2221/4885OPRM1 2267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.