Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009015 | 1.00 | PBRM1 (0.46) | PBRM1NR1I2ADRA1AADRA1BOPRK1 | |
| SCHEMBL22074808 | 0.81 | MAP3K12 (0.44) | MAP3K12CHRNA7KCNH2TLR9TLR8 | |
| SCHEMBL26241051 | 0.80 | CHRNA7 (0.63) | PBRM1NR1I2ADRA1AADRA1BOPRK1 | |
| SCHEMBL18081170 | 0.80 | CHRNA7 (0.63) | PBRM1NR1I2ADRA1AADRA1BOPRK1 | |
| SCHEMBL9963412 | 0.78 | KCNA5 (0.38) | MAP3K12KCNH2 | |
| SCHEMBL9963413 | 0.78 | KCNA5 (0.38) | MAP3K12KCNH2 | |
| SCHEMBL2391993 | 0.77 | MAP3K12 (0.51) | MAP3K12CHRNA7KCNH2TLR9TLR8 | |
| SCHEMBL16232095 | 0.77 | CHRNA7 (0.46) | PBRM1NR1I2ADRA1AADRA1BOPRK1 | |
| SCHEMBL19368143 | 0.76 | MAP3K12 (0.39) | MAP3K12CHRNA7KCNH2 | |
| SCHEMBL9963408 | 0.73 | LMNA (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | SMARCC1, SMARCC2, SMARCA4 | PBRM1 11/4885NR1I2 283/4885ADRA1A 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.