Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21937593 | 0.89 | FFAR4 (0.45) | FFAR4AKR1C3AKR1C1SIGMAR1SLC18A3 | |
| SCHEMBL21937589 | 0.87 | FFAR4 (0.43) | FFAR4AKR1C3AKR1C1HCRTR2SIGMAR1 | |
| SCHEMBL16838837 | 0.79 | AKR1C3 (0.47) | FFAR4AKR1C3AKR1C1HCRTR2SIGMAR1 | |
| SCHEMBL10895189 | 0.73 | AKR1C3 (0.61) | AKR1C3AKR1C1SIGMAR1SLC18A3LMNA | |
| SCHEMBL12733197 | 0.71 | SLC18A3 (0.48) | AKR1C3AKR1C1HCRTR2SIGMAR1SLC18A3 | |
| SCHEMBL22350946 | 0.71 | SLC18A3 (0.48) | AKR1C3AKR1C1HCRTR2SIGMAR1SLC18A3 | |
| SCHEMBL18710338 | 0.71 | SLC18A3 (0.48) | AKR1C3AKR1C1HCRTR2SIGMAR1SLC18A3 | |
| SCHEMBL18574578 | 0.71 | SLC18A3 (0.48) | AKR1C3AKR1C1SIGMAR1SLC18A3DRD2 | |
| SCHEMBL15299169 | 0.70 | HCRTR2 (0.40) | HCRTR2SIGMAR1SLC18A3DRD2 | |
| SCHEMBL11519380 | 0.70 | SLC18A3 (0.52) | AKR1C3AKR1C1SIGMAR1SLC18A3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | SMARCC1, SMARCC2, SMARCA4 | FFAR4 4258/4885AKR1C3 2261/4885AKR1C1 2328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.