Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009112 | 0.89 | FFAR4 (0.56) | FFAR4SLC18A3SIGMAR1KCNH2DRD2 | |
| SCHEMBL21937589 | 0.82 | FFAR4 (0.43) | FFAR4SLC18A3SIGMAR1KCNH2DRD2 | |
| SCHEMBL22350946 | 0.78 | SLC18A3 (0.48) | SLC18A3SIGMAR1GRIN2BDRD2CYP2D6 | |
| SCHEMBL18574578 | 0.78 | SLC18A3 (0.48) | SLC18A3SIGMAR1KCNH2HRH3GRIN2B | |
| SCHEMBL18710338 | 0.78 | SLC18A3 (0.48) | SLC18A3SIGMAR1GRIN2BDRD2CYP2D6 | |
| SCHEMBL12733197 | 0.78 | SLC18A3 (0.48) | SLC18A3SIGMAR1GRIN2BDRD2CYP2D6 | |
| SCHEMBL11614058 | 0.78 | GRIA1 (0.50) | FFAR4KCNH2HRH3 | |
| SCHEMBL11519380 | 0.77 | SLC18A3 (0.52) | SLC18A3SIGMAR1GRIN2BDRD2CYP2D6 | |
| SCHEMBL15299169 | 0.76 | HCRTR2 (0.40) | SLC18A3SIGMAR1DRD2KDM4E | |
| SCHEMBL190417 | 0.76 | SLC18A3 (0.67) | SLC18A3SIGMAR1GRIN2BDRD2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220144829-A1 | AMINO ACID COMPOUNDS AND METHODS OF USE | PLIANT THERAPEUTICS, INC. | 2022-05-12 | — | — | US | disclosed |
| US-11180494-B2 | Substituted amino acids as integrin inhibitors | PLIANT THERAPEUTICS, INC. (US) | 2021-11-23 | — | — | US | disclosed |
| US-20200109141-A1 | AMINO ACID COMPOUNDS AND METHODS OF USE | PLIANT THERAPEUTICS, INC. | 2020-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144829-A1 | AMINO ACID COMPOUNDS AND METHODS OF USE | ITGB6, ITGA1, ITGAL | FFAR4 574/4885SLC18A3 829/4885SIGMAR1 435/4885 |
| US-20200109141-A1 | AMINO ACID COMPOUNDS AND METHODS OF USE | ITGB6, ITGA1, ITGAL | FFAR4 574/4885SLC18A3 829/4885SIGMAR1 435/4885 |
| US-11180494-B2 | Substituted amino acids as integrin inhibitors | ITGB6, ITGA1, ITGB1 | FFAR4 750/4885SLC18A3 1055/4885SIGMAR1 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.