Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.48 |
| ▸ | RAF1 | P04049 | 18/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3936862 | 0.80 | BRAF (0.57) | BRAFRAF1CYP2C9 | |
| SCHEMBL3944249 | 0.78 | BRAF (0.56) | BRAFRAF1CYP2C9 | |
| SCHEMBL26075590 | 0.76 | RAF1 (0.55) | BRAFRAF1 | |
| SCHEMBL26075758 | 0.75 | RAF1 (0.58) | BRAFRAF1 | |
| SCHEMBL29877984 | 0.75 | RAF1 (0.58) | BRAFRAF1 | |
| SCHEMBL3939108 | 0.74 | BRAF (0.78) | BRAFCYP2C9 | |
| SCHEMBL20008430 | 0.74 | RAF1 (0.48) | BRAFRAF1 | |
| SCHEMBL3933224 | 0.73 | BRAF (0.62) | BRAFRAF1CYP2C9 | |
| SCHEMBL29877572 | 0.72 | MAPT (0.58) | BRAFRAF1 | |
| SCHEMBL3934840 | 0.72 | BRAF (0.78) | BRAFRAF1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |