Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 19/20 | 0.62 |
| ▸ | BRAF | P15056 | 3/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008578 | 0.87 | RAF1 (0.60) | RAF1BRAFMAPK13KDRMAPK12 | |
| SCHEMBL20008577 | 0.87 | RAF1 (0.59) | RAF1BRAF | |
| SCHEMBL20008579 | 0.86 | RAF1 (0.60) | RAF1BRAF | |
| SCHEMBL20009424 | 0.86 | RAF1 (0.60) | RAF1BRAF | |
| SCHEMBL17523505 | 0.85 | RAF1 (0.76) | RAF1BRAF | |
| SCHEMBL17523501 | 0.85 | RAF1 (0.76) | RAF1BRAF | |
| SCHEMBL20010355 | 0.84 | RAF1 (0.44) | RAF1BRAF | |
| SCHEMBL20264516 | 0.76 | RAF1 (1.00) | RAF1BRAF | |
| SCHEMBL20264480 | 0.76 | RAF1 (1.00) | RAF1BRAF | |
| SCHEMBL20264713 | 0.74 | RAF1 (1.00) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |