Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 20/20 | 0.60 |
| ▸ | BRAF | P15056 | 6/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | ARAF | P10398 | 1/20 | 0.52 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009424 | 1.00 | RAF1 (0.60) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL20008577 | 0.87 | RAF1 (0.59) | RAF1BRAF | |
| SCHEMBL20009426 | 0.86 | RAF1 (0.62) | RAF1BRAF | |
| SCHEMBL17523503 | 0.85 | RAF1 (0.76) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL17523507 | 0.85 | RAF1 (0.76) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL20010355 | 0.83 | RAF1 (0.44) | RAF1BRAF | |
| SCHEMBL17523499 | 0.81 | RAF1 (0.77) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL17523502 | 0.81 | RAF1 (0.77) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL20008470 | 0.79 | RAF1 (0.66) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL20264662 | 0.75 | RAF1 (1.00) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |