Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23679890 | 0.88 | NAMPT (0.40) | NAMPTKDM1ANR1H2OPRD1DRD2 | |
| SCHEMBL20012324 | 0.83 | NAMPT (0.40) | NAMPTKDM1ANR1H2OPRD1DRD2 | |
| SCHEMBL11969272 | 0.81 | OPRD1 (0.52) | KDM1AOPRD1DRD2DPP4MEN1 | |
| SCHEMBL11969924 | 0.80 | KDM1A (0.55) | KDM1AOPRD1DRD2DPP4MEN1 | |
| SCHEMBL11993884 | 0.76 | ABCB1 (0.41) | NR1H2ABCB1 | |
| SCHEMBL16080305 | 0.76 | NR1H2 (0.51) | NR1H2ABCB1DPP4 | |
| SCHEMBL23691566 | 0.74 | ATM (0.41) | NR1H2MEN1KMT2ACYP1A2POLB | |
| SCHEMBL8064836 | 0.74 | SRC (0.41) | NAMPTNR1H2HDAC8 | |
| SCHEMBL12926208 | 0.73 | SRC (0.39) | NAMPTNR1H2ABCB1MEN1KMT2A | |
| SCHEMBL19674208 | 0.72 | HSD17B10 (0.40) | NAMPTNR1H2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3363437-B1 | AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN | ENDO PHARMACEUTICALS SOLUTIONS (US) | 2021-07-28 | — | — | EP | disclosed |
| EP-2675787-B1 | AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN | ENDO PHARMACEUTICALS INC (US) | 2018-03-28 | — | — | EP | disclosed |