Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 8/20 | 0.49 |
| ▸ | SMARCA2 | P51531 | 6/20 | 0.49 |
| ▸ | SMARCA4 | P51532 | 6/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | ABL2 | P42684 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30606896 | 0.83 | PBRM1 (0.66) | PBRM1SMARCA2SMARCA4EGFRSRC | |
| SCHEMBL18038859 | 0.83 | PBRM1 (0.66) | PBRM1SMARCA2SMARCA4EGFRSRC | |
| SCHEMBL30606905 | 0.80 | SMARCA2 (0.71) | PBRM1SMARCA2SMARCA4GPR119SMN1; SMN2 | |
| SCHEMBL20009090 | 0.80 | SMARCA2 (0.71) | PBRM1SMARCA2SMARCA4GPR119SMN1; SMN2 | |
| SCHEMBL18080979 | 0.76 | PBRM1 (0.48) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL18038743 | 0.74 | PBRM1 (0.47) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL18038861 | 0.72 | TP53 (0.46) | PBRM1SMARCA2SMARCA4SMN1; SMN2NR1I2 | |
| SCHEMBL20012501 | 0.70 | PBRM1 (0.46) | PBRM1SMARCA2SMARCA4HTTNR1I2 | |
| SCHEMBL18038829 | 0.70 | PBRM1 (0.50) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL18038722 | 0.70 | PBRM1 (0.61) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10308614-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-06-04 | — | — | US | disclosed |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308614-B2 | Therapeutic compounds and uses thereof | SMARCC1, SMARCC2, SMARCA4 | PBRM1 11/4885SMARCA2 10/4885SMARCA4 3/4885 |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | SMARCC1, SMARCC2, SMARCA4 | PBRM1 11/4885SMARCA2 10/4885SMARCA4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.