Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 19/20 | 0.66 |
| ▸ | SMARCA2 | P51531 | 15/20 | 0.66 |
| ▸ | SMARCA4 | P51532 | 15/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18038859 | 1.00 | PBRM1 (0.66) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL20009090 | 0.94 | SMARCA2 (0.71) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL30606905 | 0.94 | SMARCA2 (0.71) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL31548738 | 0.83 | SMARCA2 (0.65) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL14046508 | 0.83 | SMARCA2 (0.54) | PBRM1SMARCA2SMARCA4EGFRSRC | |
| SCHEMBL20012564 | 0.83 | PBRM1 (0.49) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL14028510 | 0.83 | SMARCA2 (0.53) | PBRM1SMARCA2SMARCA4EGFRSRC | |
| SCHEMBL18038722 | 0.82 | PBRM1 (0.61) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL18080998 | 0.81 | PBRM1 (0.51) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL4947972 | 0.81 | SMARCA2 (0.51) | PBRM1SMARCA2SMARCA4EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262036-B1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2023-09-13 | — | — | EP | disclosed |