Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.57 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | CDK4 | P11802 | 2/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20012916 | 0.88 | JAK2 (0.60) | EGFRAURKACDK4ALKJAK2 | |
| SCHEMBL20012950 | 0.87 | AURKA (0.54) | EGFRAURKACDK4ALKJAK2 | |
| SCHEMBL20012912 | 0.87 | ALK (0.62) | EGFRAURKACDK4FGFR1ALK | |
| SCHEMBL20012904 | 0.87 | CDK4 (0.54) | EGFRAURKACDK4FGFR1ALK | |
| SCHEMBL20012983 | 0.85 | EGFR (0.54) | EGFRAURKACDK4ALKKDR | |
| SCHEMBL20012926 | 0.80 | MKNK1 (0.62) | EGFRAURKACDK4ALKKDR | |
| SCHEMBL20012909 | 0.79 | PDGFRB (0.50) | EGFRAURKACDK4FGFR1ALK | |
| SCHEMBL14330683 | 0.78 | ALK (0.64) | EGFRFGFR1ALKKDRTNK2 | |
| SCHEMBL3274766 | 0.76 | IGF1R (0.77) | EGFRFGFR1ALKBRD4 | |
| SCHEMBL20012903 | 0.75 | SYK (0.53) | AURKACDK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018056621-A1 | NOVEL IMIDAZOLYL PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER | 재단법인 대구경북첨단의료산업진흥재단 | 2018-03-29 | — | — | WO | disclosed |