Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 4/20 | 0.49 |
| ▸ | STAT6 | P42226 | 3/20 | 0.48 |
| ▸ | CDK4 | P11802 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20012906 | 0.90 | CDK4 (0.46) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL20012904 | 0.88 | CDK4 (0.54) | JAK2CDK4AURKATTKCCND3 | |
| SCHEMBL20012902 | 0.84 | INSR (0.60) | IGF1RTTK | |
| SCHEMBL20012919 | 0.84 | ALK (0.58) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL20012936 | 0.84 | WEE1 (0.47) | SYKJAK2JAK1JAK3CDK4 | |
| SCHEMBL20012909 | 0.81 | PDGFRB (0.50) | JAK2IGF1RCDK4AURKACCND3 | |
| SCHEMBL20012991 | 0.78 | FGFR1 (0.53) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL20012920 | 0.77 | TTK (0.57) | IGF1RTTK | |
| SCHEMBL20012916 | 0.76 | JAK2 (0.60) | JAK2CDK4AURKACCND3CCNK | |
| SCHEMBL20012911 | 0.75 | EGFR (0.57) | JAK2CDK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018056621-A1 | NOVEL IMIDAZOLYL PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER | 재단법인 대구경북첨단의료산업진흥재단 | 2018-03-29 | — | — | WO | disclosed |