Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | TEC | P42680 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40697 | 0.83 | PDGFRB (0.50) | PDGFRBPDGFRANR4A2KCNH2TDP1 | |
| SCHEMBL29904777 | 0.83 | PDGFRB (0.50) | PDGFRBPDGFRANR4A2KCNH2TDP1 | |
| SCHEMBL20012970 | 0.82 | DAO (0.46) | PDGFRBPDGFRANR4A2TECPIK3CD | |
| SCHEMBL25728286 | 0.81 | HTR2A (0.47) | PIK3CDKCNH2HTR2AHTR2CHTR2B | |
| SCHEMBL23747186 | 0.81 | KLKB1 (0.33) | HTR2AHTR2CHTR2BKLKB1MAP4K1 | |
| SCHEMBL20009337 | 0.80 | HRH4 (0.38) | PDGFRBPDGFRANR4A2HRH4FGFR3 | |
| SCHEMBL21880734 | 0.79 | MET (0.41) | KCNH2 | |
| SCHEMBL24758455 | 0.79 | HTR2A (0.47) | PIK3CDKCNH2HTR2AHTR2CHTR2B | |
| SCHEMBL3632278 | 0.77 | PDGFRB (0.45) | PDGFRBPDGFRANR4A2KCNH2TDP1 | |
| SCHEMBL21282890 | 0.77 | HTR2A (0.35) | PIK3CDALOX5APHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10479770-B2 | Phosphatidylinositol 3-kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2019-11-19 | — | — | US | disclosed |
| US-20180086719-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086719-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, AKT3, PI4KA | PDGFRB 829/4885PDGFRA 964/4885NR4A2 2935/4885 |
| US-10479770-B2 | Phosphatidylinositol 3-kinase inhibitors | PIK3CA, AKT3, PI4KA | PDGFRB 829/4885PDGFRA 964/4885NR4A2 2935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.