Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 6/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | DHODH | Q02127 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15452447 | 0.81 | CYP3A4 (0.84) | CYP2C9MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL17689204 | 0.81 | CYP2C9 (0.80) | CYP2C9MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL17689183 | 0.78 | MAPT (0.69) | CYP2C9MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL14970875 | 0.77 | CYP3A4 (1.00) | CYP2C9MAPTALDH1A1L3MBTL1KMT2A | |
| SCHEMBL17689191 | 0.77 | CYP2C9 (0.72) | CYP2C9MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL17681393 | 0.76 | CYP2C9 (0.70) | CYP2C9MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL17689217 | 0.76 | MAPT (0.86) | CYP2C9MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL13312263 | 0.75 | CYP2C9 (0.73) | CYP2C9MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL1901619 | 0.74 | DHODH (0.90) | CYP2C9MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL8304200 | 0.74 | MAPT (0.59) | CYP2C9NPSR1MAPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4275759-A2 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | Dana-Farber Cancer Institute, Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| EP-3515449-B1 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | DANA FARBER CANCER INST INC (US) | 2023-07-12 | — | — | EP | disclosed |
| WO-2018058029-A1 | CHROMOBOX PROTEIN INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-03-29 | — | — | WO | disclosed |