Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 19/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22105024 | 0.86 | SMPD3 (0.57) | SMPD3 | |
| SCHEMBL20016011 | 0.85 | SMPD3 (0.56) | SMPD3 | |
| SCHEMBL19559977 | 0.83 | SMPD3 (0.59) | SMPD3 | |
| SCHEMBL19467164 | 0.80 | AAK1 (0.62) | SMPD3 | |
| SCHEMBL15280681 | 0.80 | SMPD3 (0.68) | SMPD3 | |
| SCHEMBL24689691 | 0.80 | SMPD3 (0.68) | SMPD3PIM1PIM2 | |
| SCHEMBL25968370 | 0.79 | SMPD3 (0.52) | SMPD3 | |
| SCHEMBL20015997 | 0.79 | SMPD3 (0.68) | SMPD3 | |
| SCHEMBL15989384 | 0.77 | SMPD3 (0.68) | SMPD3 | |
| SCHEMBL18968044 | 0.77 | SMPD3 (1.00) | SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299372-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OFSUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2018-03-28 | — | — | EP | disclosed |