Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.38 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NEU1 | Q99519 | 1/20 | 0.33 |
| ▸ | NEU3 | Q9UQ49 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23626511 | 0.84 | ANPEP (0.41) | ALDH1A1ANPEPCA1DNPEPRNPEP | |
| SCHEMBL19818505 | 0.81 | ALDH1A1 (0.44) | ALDH1A1CA1HPGDP2RX7CYP2D6 | |
| SCHEMBL9349283 | 0.80 | CYP2D6 (0.52) | ALDH1A1CA1HPGDCYP2D6CYP2C19 | |
| SCHEMBL22912616 | 0.79 | ALDH1A1 (0.42) | ALDH1A1ANPEPCA1DNPEPRNPEP | |
| SCHEMBL18769009 | 0.77 | SMN1; SMN2 (0.39) | ALDH1A1HPGDPSMB5CYP2D6CYP2C19 | |
| SCHEMBL24391761 | 0.75 | ALDH1A1 (0.45) | ALDH1A1ANPEPCA1DNPEPHPGD | |
| SCHEMBL23106272 | 0.74 | HPGD (0.45) | ALDH1A1HPGDCYP2D6CYP2C19LMNA | |
| SCHEMBL21658063 | 0.73 | ALDH1A1 (0.52) | ALDH1A1ANPEPCA1DNPEPRNPEP | |
| SCHEMBL19818495 | 0.73 | CYP2D6 (0.45) | ALDH1A1CA1HPGDPSMB5CYP2D6 | |
| SCHEMBL24450393 | 0.73 | HPGD (0.38) | ALDH1A1HPGDPSMB5EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11312964-B2 | Compositions and methods for modulating growth hormone receptor expression | IONIS PHARMACEUTICALS, INC. (US) | 2022-04-26 | — | — | US | disclosed |
| US-20210207146-A1 | COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION | IONIS PHARMACEUTICALS, INC. (US) | 2021-07-08 | — | — | US | disclosed |
| US-9957292-B2 | Compositions and methods for modulating angiopoietin-like 3 expression | IONIS PHARMACEUTICALS, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-9932581-B2 | Compositions and methods for modulating apolipoprotein C-III expression | IONIS PHARMACEUTICALS, INC. (US) | 2018-04-03 | — | — | US | disclosed |