Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.45 |
| ▸ | MASP2 | O00187 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21553910 | 0.91 | PLAU (0.52) | MEN1KMT2APOLBMASP2PLAU | |
| SCHEMBL18938347 | 0.88 | KMT2A (0.61) | MEN1KMT2APOLBGRIN2BGRIN1 | |
| SCHEMBL18891443 | 0.81 | PBRM1 (0.55) | MEN1KMT2APOLBGRIN2BGRIN1 | |
| SCHEMBL24022828 | 0.80 | NPC1 (0.61) | MEN1KMT2APOLBGRIN2BGRIN1 | |
| SCHEMBL22044257 | 0.80 | CYP2D6 (0.66) | MEN1KMT2APOLBGRIN2BGRIN1 | |
| SCHEMBL31099419 | 0.79 | NPFFR1 (0.50) | MEN1KMT2AMASP2PLAUTHPO | |
| SCHEMBL6967013 | 0.78 | MEN1 (0.76) | MEN1KMT2APOLBGRIN2BGRIN1 | |
| SCHEMBL6649650 | 0.78 | POLB (0.49) | MEN1KMT2APOLBTSHRRAB9A | |
| SCHEMBL6791698 | 0.78 | POLB (0.49) | MEN1KMT2APOLBTSHRRAB9A | |
| SCHEMBL24689825 | 0.77 | KMT2A (0.45) | MEN1KMT2APOLBGRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9931408-B2 | Bio-orthogonal drug activation | KONINKLIJKE PHILIPS N.V. (NL) | 2018-04-03 | — | — | US | disclosed |