Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2739057 | 0.85 | MAPT (0.49) | MAPTKMT2ARAB9ALMNANPC1 | |
| SCHEMBL15443857 | 0.83 | LMNA (0.44) | MAPTKMT2ARAB9ALMNANPC1 | |
| SCHEMBL2739055 | 0.82 | MAPT (0.46) | MAPTKMT2ARAB9ALMNANPC1 | |
| SCHEMBL25775999 | 0.75 | — | — | |
| SCHEMBL217410 | 0.75 | LMNA (0.49) | MAPTKMT2ARAB9ALMNANPC1 | |
| SCHEMBL2739058 | 0.75 | MAPT (0.51) | MAPTKMT2ARAB9ALMNANPC1 | |
| SCHEMBL19981575 | 0.75 | MAPT (0.47) | MAPTKMT2ARAB9ALMNANPC1 | |
| SCHEMBL219989 | 0.74 | LMNA (0.45) | MAPTKMT2ARAB9ALMNANPC1 | |
| SCHEMBL10498542 | 0.73 | LMNA (0.70) | MAPTKMT2ARAB9ALMNANPC1 | |
| SCHEMBL6663539 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788487-B1 | OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-04-04 | — | — | EP | disclosed |